Effectiveness of Open Surgery for Supratentorial Gliomas in Terms of Improvement in Karnofsky Performance Score

Authors

  • ZAHID KHAN Department of Neurosurgery
  • RAZA AMAN Department of Neurosurgery
  • MUMTAZ ALI Department of Neurosurgery
  • Seema Sharafat Department of Neurosurgery
  • Ramzan Hussain Department of Neurosurgery,

Keywords:

Open surgery, supra-tentorial glioma, effectiveness

Abstract

Introduction: Glioma is a primary brain tumor derived from neuralgia cells like astrocytes, oligodendrocytes and ependymal cells. It is a non curable malignant tumor. Therefore, the objective of the treatment is mainly to improve quality of life.
Objective: To determine the effectiveness of open surgery for supra-tentorial glioma in terms of improvement in Karnofsky performance score.
Materials and Method: This Descriptive case series study was conducted at Neurosurgery Department PGMI / LRH Peshawar from January 2012 to December 2012 (1 year). Total 144 consecutive patients with supra-tentorial glioma of more than 18 years of age who underwent open surgery (craniotomy with tumor resection) were included. Pre and postoperative Karnofsky performance score was recorded.
Results: Total of 144 patients were included in the study, of which 101 were males and 43 females. Age ranged from 19 years to 65 years with 36.8% of the patients in the 3rd decade of life. Majority of the patients had supra-tentorial glioma in the frontal lobe making 38.9% of the whole. In 63.9% of the patients, the procedure was effective. It was more effective in young individuals as compared to patients of middle and old age. Furthermore, the success rate was more in patients with frontal lobe tumor followed by those with parietal glioma.
Conclusion: Open surgery with total or partial resection of tumor is an effective procedure for the treatment of supra-tentorial glioma. Its effectiveness is influenced by the age of patient, location of the tumor and preoperative Karnofsky performance score.

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Published

2018-09-30

Issue

Vol. 17 No. 2 (2013): July-December

Section

Original Articles

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The work published by PJNS is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Copyrights on any open access article published by Pakistan Journal of Neurological Surgery are retained by the author(s).