Frequency of Elevated Mean Platelet Volume in Patients with Different Severities of Acute Ischemic Stroke
Keywords:
Stroke, Modified Rankin Score, Mean Platelet volumeAbstract
Objective: Determine the frequency of elevated mean platelet volume in patients with different severities of acute ischemic stroke who presented in Lahore general hospital Lahore.
Study Design: Cross sectional survey.
Duration: Study duration was 1year.
Sample Size: 130 patients of acute ischemic stroke.
Sample Technique: Non-probability purposive sampling.
Methodology: Consecutive 130 patients of acute ischemic stroke presented to emergency department or admitted through OPD within 24 hours of onset of symptoms and fulfilling the inclusion criteria were selected. Patients were divided in two groups based on mRS scoring. MPV was measured by automated hematology analyser Sysmex KX-21. The severity of stroke was assessed by Modified Rankin Score (mRS) between 24 to 72 hours of onset of symptoms.Patients with acute ischemic stroke proved by CT brain presenting within 24 hours of symptom onset and Age 40 and above and both genders were include. Patients with hematological malignancies were excluded from study.
Data Collection: 130 patients admitted patients (through emergency and outdoor), Lahore General Hospital, Lahore fulfilling the inclusion criteria were selected for study.The severity of stroke was assessed by modified Rankin Scoring (mRS). The patients were divided in to two groups based on mRS scoring. Mean platelet volume and mRS score were recorded. Major risk factors like hypertension, diabetes mellitus, smoking history and hypercholesterolemia if present were also recorded. The demographic information of these cases like name, age, sex and address recorded. The collected information was entered into SPSS version 11.0. Quantitative variables like age, mean platelet volume were analyzed as mean and standard deviation. Frequencies of elevated MPV in both groups were described. Gender and severity of stroke (mild, moderate to severe) were analysed as frequency and percentage. Elevated MPV was also analysed as frequency and percentage in both groups
Results: Among the enrolled 130 patients 80 (61.5%) were males and 50 (38.5%) were females (Table 1, Graph 1) with age ranging from 41 – 74 years with a mean age of 56.85 ± 10.15 years. 45 (35%) patients had modified Rankin scale (mRS) between 0 to 2 while 85 (65%) patients had mRS between 3 to 6. Overall mean platelet volume was found to be elevated in 85 patients. Among them 62 (73%) patients had mRS of 3 – 6 (group 2) while 23 patients had mRS of 0 – 2 (group 1). Among the 45 (23%) patients who had normal mean platelet volume, 22 belonged to group 1 (mRS 0 – 2) while 23 were in group 2 (mRS 3 – 6).
Conclusion: MPV, with an easy way of measurement, may be anearly and important predictor for the prognosis of ischemic stroke.
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