Intracranial Low Grade Glioma: a Clinical Study of 35 Cases in a Teaching Institute

  • SOHAIL AMIR Department of Neurosurgery, Hayatabad Medical Complex, Peshawar
  • GOHAR ALI Department of Neurosurgery, Mardan Medical Complex, Mardan
  • KHALID MEHMOOD Department of Neurosurgery, Mardan Medical Complex, Mardan – Pakistan
  • NAEEM-UL HAQ Department of Neurosurgery, Mardan Medical Complex, Mardan
Keywords: Low grade Glioma, Karnofsky performance score, Seizure


Objective: To determine the clinical manifestation and surgical outcome of patients with low grade Glioma.
Material and Methods: This descriptive (cross sectional) study was done at the Neurosurgery Department, Mardan Medical Complex Mardan. The study period was March 2017 to February 2018. Patient of any age and gender presented to outpatient department or referred from some other medical facility and diagnosed as low grade Glioma on clinical and radiological grounds and later confirmed by histopathology were included. 
Results: Out of 35 patients, 20 (57%) were male and 15 (42%) were female. 20 to 80 years was the age range and mean age was 46.36 ± 17.11 years. Frontal lobe was the most frequent area of location, followed by parietal 9 (25%) and temporal 8 (22%) lobe. Pre-operativeKarnofsky score was 90 in 16 (45%), 80 in 8 (22%), 70 in 6 (17%) and 60 in 5 (14%) of patients. Gross total resection was achieved in 13 (37%), radical subtotal resection in 10 (28%), subtotal resection in 10 (28%) and biopsy taken in 02 (5%) patients. histopathology revealed Astrocytoma in 15 (42%), mixed Oligoastrocytoma in 12 (34%) and Oligodendroglioma in 8 (22%) number of patients. Post operatively surgical outcome was measured by improvement in symptomatology, Karnofsky score and seizure control. 
Conclusion: Conscious level, Karnofsky Performance score, seizure control are important parameters for surgical outcome in patients with low grade Gliomas. Gross total resection of the tumor is a better option for good surgical outcome.


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Original Article