Magnetic Resonance Spectroscopic and Histopathological Findings in the Supratentorial Brain Space Occupying Lesions

  • ASAD ABBAS Jinnah Postgraduate Medical Center, Karachi
  • FARRUKH JAVEED Department of Neurosurgery, Jinnah Postgraduate Medical Centre, Karachi
  • LAL REHMAN Department of Neurosurgery, Jinnah Postgraduate Medical Centre, Karachi
  • ALI AFZAL Department of Neurosurgery, Jinnah Postgraduate Medical Centre, Karachi
  • RAZA KHAIRAT RIZVI Department of Neurosurgery, Jinnah Postgraduate Medical Centre, Karachi
Keywords: Magnetic Resonance Spectroscopy, Supratentorial lesion, Brain Tumor, Brain Abscess


Objective:  Diagnosis of supratentorial space occupying lesion is a frequent dilemma in neurosurgical practice. MR spectroscopy that is an advanced MR imaging sequence can prove to be decisive in such cases. The objective of the study is to determine diagnostic accuracy of MRS in differentiating supra-tentorial brain space occupying lesions taking histopathology as gold standard

Material and Methods:  The cross sectional study was conducted at Department of Neurosurgery, Jinnah Postgraduate Medical Centre, Karachi from August 2018 to July 2019. A calculated sample size of 156 patients aged between 18-50 years after informed consent. All patients underwent MR Spectroscopy pre-operatively. Surgery was performed and histopathological findings were compared with spectroscopic findings.

Results:  The average age of the patients was 32.41 ± 10.02 years. There were 84 (53.84%) males and 72 (46.15%) females. The sensitivity of MRS was 90.69% with a specificity of 97.34%.

Conclusion:  MR Spectroscopy is an accurate diagnostic tool for establishing pre-operative differentiation between neoplastic and inflammatory lesion. It should be performed in all cases where contrast MRI is inconclusive in establishing the diagnosis.

Keywords:  , Brain Abscess, Supratentorial lesion, Brain Tumor


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Original Article