Incidence and Predisposing factors of Brain Abscess in Children at a Tertiary Care Center Dera Ghazi Khan


  • Syed Shahid Bokhari Ghazi Khan Medical College and Teaching Hospital Dera Ghazi Khan, Pakistan
  • Muhammad Asif Qureshi Department of Pediatric Surgery, Ghazi Khan Medical College and Teaching Hospital Dera Ghazi Khan



Objective:  A cross sectional study was aimed to investigate the incidence and predisposing factors of brain abscess in children.

Material and Methods:  The study was conducted in the departments of Neurosurgery and Pediatric Surgery, Ghazi Khan Medical College and Hospital DG khan. Thirty two children with brain abscess were enrolled in the study. A diagnosis of brain abscess was made on clinical and radiological basis. T-test and chi square were applied to see the association between variables.

Results:  Most common location of Abscess was found as frontal in 21.9% patients, temporo parietal in 53.1% patients and occipital in 25.0% patients. Streptococci was the most common microorganism on culture reported, noted in 46.9% patients. Major predisposing factors (p = 0.000) and location of abscess
(p = 0.003) were the effect modifiers for microorganism on culture reports.

Conclusion:  Streptococci was the most common abscess causing microorganism causing about 47% of total abscess causing pathogens. Main predisposing factors were: otitis media, cyanotic heart disease and post head injury otorrhea.

Keywords:  Brain abscess; Children; Otogenic brain abscess; Otitis media, Seizures; Streptococci.


1. Acar M, Sutcu M, Akturk H, Muradova A, Torun SH, Salman N. Evaluation of short-term neurological outcomes in children with brain abscesses. Turk Neurosurg. 2018; 28: 79-87.
2. Jain A, Arora N, Meher R, Passey JC, Bansal R. Intracranial complications of CSOM in pediatric patients: A persisting problem in developing countries. Int J Pediatr Otorhinolaryngol. 2017; 100: 128-31.
3. Singh A, Abhinay A, Prasad R, Mishra OP. Neonatal brain abscess: Clinical report and review of Indian cases. J Clin Neonatol. 2016; 5: 213-7.
4. Nicolosi A, Hauser W, A, Musicco M, Kurland L, T: Incidence and Prognosis of Brain Abscess in a Defined Population: Olmsted County, Minnesota, 1935–1981. Neuroepidemiology. 1991; 10: 122-131. Doi: 10.1159/000110257
5. Acar M, Sutcu M, Akturk H, Muradova A, Torun SH, Salman N. Evaluation of Short-Term Neurological Outcomes in Children with Brain Abscesses. Turk Neurosurg. 2018; 28 (1): 79-87. Doi: 10.5137/1019-5149.JTN.18672-16.1. PMID: 27858396.
6. Mameli C, Genoni T, Madia C. Brain abscess in pediatric age: a review. Childs Nerv Syst. 2019; 35: 1117–1128.
7. Zhang Z, Cai X, Li J, Kang X, Wang H, Zhang L et al. Retrospective analysis of 620 cases of brain abscess in Chinese patients in a single center over a 62-year period. Acta Neurochir. 2016; 158: 733–739.
8. Sonneville R, Magalhaes E, Meyfroidt G. Central nervous system infections in immunocompromised patients. Curr Opin Crit Care, 2017; 23 (2): 128–133.
9. Shovlin CL, Condliffe R, Donaldson JW, Kiely DG, Wort SJ. On behalf of the British Thoracic Society. British Thoracic Society clinical statement on pulmonary arteriovenous malformations. Thorax. 2017; 72: 1154–1163.
10. SahbudakBal Z, Eraslan C, Bolat E, Avcu G, Kultursay N, Ozkinay F et al. Brain abscess in children: a rare but serious infection. Clin Pediatr (Phila). 2018; 57 (5): 574–579.






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