Incidence and Trends of Neural Tube Defects in Babies Delivered at Dera Ghazi Khan Tertiary Care Center
DOI:
https://doi.org/10.36552/pjns.v24i4.496Abstract
Objective: A cross-section study was conducted to determine the incidence and trends of neural tube defects in babies delivered at a tertiary care center. And those babies who were delivered elsewhere and were brought to a tertiary care center for treatment.
Material and Methods: The Study was conducted at neurosurgery and pediatric surgery departments, Ghazi Khan Medical College and Teaching Hospital. Two thousand (n = 2000) women delivered their babies at a tertiary care hospital were enrolled, out of them 52 women who delivered babies with neural tube defects (NTDs) were further assessed. Women were interviewed and history of folic acid intake, previous baby with NTDs and family history were recorded. Tests of significance were applied to assess the significant results.
Results: Folic acid intake was occurred in n = 298 (14.9%) subjects. Association of folic acid on neural tube defects. Odds ratio showed that if a baby without intake of folic acid had 7.8 times at risk to suffer from a neural tube defect. The association was also significant (p = 0.000).
Conclusion: Neural tube defects are common in tertiary care centers its incidence was 2%. Increased incidence of NTDs was observed in babies who delivered by folic acid deficit mothers. Early childhood marriages in rural areas and cousin marriages are the main contributing factors.
Keywords: Neural tube defect, Anencephaly, Spina bifida, Hydrocephalus, Meningocele.
References
Doi: 10.11648/j.sjph.20170506.17
2. Zaganjor I, Sekkarie A, Tsang BL, Williams J, Razzaghi H, Mulinare J et al. Describing the prevalence of neural tube defects worldwide: A systematic literature review. PloS one, 2016; 11; 11 (4): e0151586.
3. Liu J, Li Z, Greene NDE, Li H, Ren A. The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China. Oncotarget. 2017; 8 (42): 72577-72583.
Doi:10.18632/oncotarget.19890
4. Turner MJ. Neural Tube Defects and Folic Acid Food Fortification in Europe. Am J Public Health, 2018; 108 (5): 601-602.
Doi:10.2105/AJPH.2018.304389
5. Chitayat D, Matsui D, Amitai Y. Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update. J Clin Pharmacol. 2016; 56 (2): 170–175.
6. Viswanathan M, Treiman KA, Kish-Doto J, Middleton JC, Coker-Schwimmer EJ, Nicholson WK. Folic acid supplementation for the prevention of neural tube defects: an updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2017; 317 (2): 190–203.
7. Atta CA, Fiest KM, Frolkis AD et al. Global birth prevalence of spina bifida by folic acid fortification status: a systematic review and meta-analysis. Am J Public Health, 2016; 106 (1): e24–e34.
8. Khoshnood B, Loane M, de Walle H et al. Long term trends in prevalence of neural tube defects in Europe: population based study. BMJ. 2015; 351: h5949.
9. Liu S, Evans J, MacFarlane AJ, et al. Association of maternal risk factors with the recent rise of neural tube defects in Canada. Paediatr Perinat Epidemiol. 2019; 33 (2): 145-153. Doi:10.1111/ppe.12543
10. Huang HY, Chen HL, Feng LP. Maternal obesity and the risk of neural tube defects in offspring: a meta-analysis. Obes Res Clin Pract. 2017; 11: 188–197.
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