Incidence of Epilepsy and Drug Dependence after Post Traumatic Contusions Managed Conservatively
contusions managed conservatively.
Material and Methods: A prospective observational study was carried out in, Punjab Institute of Neurosciences, Lahore. A total of 97 patients, from 15-65 years, who were diagnosed with cerebral contusions and being managed conservatively were enrolled from July 2019 to December 2019. They were followed-up for 12 – 18 months.
Results: A total of 23% patients developed early post-traumatic seizures (PTS) and 11% of patients developed late post-traumatic seizures with mild to moderate brain injury.6% of patients with early PTS used antiepileptic drugs (AED) for at least three months during follow up and 7% with late PTS used AED. 8% of patients developed late PTS without any early PTS. The results of our study show that among 23% early PTS and 11% late PTS only 3 % actually required to use AED for at least 6months. To prevent this, 3% of the population 44% were using AED supplementary.
Conclusion: In our study, the incidence of early and late PTS is comparable to the other studies. The non-judicious use of the anti-epileptic drug is common in our country which leads to an increase in the risk of drug resistance and cost-intensive for poor patients in developing countries as prophylactic and excessive use of anti-epileptics does not affect the PTE.
2. Shamim S, Razzak JA, Jooma R, Khan U: Initial results of Pakistan's first road traffic injury surveillance project. International Journal of Injury Control and Safety Promotion, 2011; 18 (3): 213-217.
3. Yerram S, Katyal N, Prem kumar K, Nattanmai P, Newey CR. Seizure prophylaxis in the neuroscience intensive care unit. Journal of Intensive Care, 2018; 6 (1): 1-0.
4. Fernández-Abinader JA, González-Colón K, Feliciano CE, Mosquera-Soler AM. Traumatic Brain Injury Profile of an Elderly Population in Puerto Rico. P R Health Sci J. 2017; 36 (4): 237-239.
5. Egbohou P, Mouzou T, Tchetike P, Sama HD, Assenouwe S, Akala-Yoba G, Randolph L, Tomta K. Epidemiology of Pediatric Traumatic Brain Injury at Sylvanus Olympio University Hospital of Lomé in Togo. Anesthesiol Res Pract. 2019; 2019: 4038319.
6. AAnnegers JF, Coan SP. The risks of epilepsy after traumatic brain injury. Seizure, 2000; 1; 9 (7): 453-7.
7. Lowenstein DH. Epilepsy after head injury: an overview. Epilepsia, 2009; 50: 4-9.
8. Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, and Kobusingye OC: The impact of traumatic brain injuries: a global perspective Neuro-Rehabilitation, 2007; 22 (5): 341-353.
9. Mark SG. Handbook of Neurosurgery. 9th edition Thieme 2020, Chapter 27, Special Type of seizures; p.480-481.
10. Pellot JE, De Jesus O. Cerebral Contusion In Stat Pearls. Treasure Island (FL): Stat Pearls Publishing, 2021.
11. Jiang JY. Chinese Head Trauma Study Collaborators. Head trauma in China Injury, 2013; 44 (11): 1453-7.
12. Ding K, Gupta PK, Diaz-Arrastia R. Epilepsy after Traumatic Brain Injury. In: Laskowitz D, Grant G, editors. Translational Research in Traumatic Brain Injury. Boca Raton (FL), Chapter 14. CRC Press/ Taylor and Francis Group, 2016.
13. Yablon SA. Posttraumatic seizures. Arch Phys Med Rehabil. 1993; 74: 983–1001.
14. Agrawal A, Timothy J, Pandit L, Manju M. Post-traumatic epilepsy: an overview. Clin Neurol
Neurosurg. 2006; 108: 433–439.
15. James W. Bales, Richard G. Ellenbogen, In Principles of Neurological Surgery (Fourth Edition), 2018.
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