Incidence of Epilepsy and Drug Dependence after Post Traumatic Contusions Managed Conservatively

  • Faiq Sheikh Punjab Institute of Neurosciences Lahore, Department of Neurosurgery, Lahore
  • Rabia Saleem Punjab Institute of Neurosciences Lahore, Department of Neurosurgery, Lahore
  • Jamal Nasir Children Hospital, Lahore, Pakistan
  • Ahmed Sultan
  • Abuzar Rauf Punjab Institute of Neurosciences Lahore, Department of Neurosurgery, Lahore,
  • Muhammad Anwar Chaudhary Punjab Institute of Neurosciences Lahore, Department of Neurosurgery
Keywords: Post Traumatic Epilepsy, Anti-Epileptic Drugs, Traumatic Brain Injury

Abstract

contusions managed conservatively.

Material and Methods:  A prospective observational study was carried out in, Punjab Institute of Neurosciences, Lahore. A total of 97 patients, from 15-65 years, who were diagnosed with cerebral contusions and being managed conservatively were enrolled from July 2019 to December 2019. They were followed-up for 12 – 18 months.

Results:  A total of 23% patients developed early post-traumatic seizures (PTS) and 11% of patients developed late post-traumatic seizures with mild to moderate brain injury.6% of patients with early PTS used antiepileptic drugs (AED) for at least three months during follow up and 7% with late PTS used AED. 8% of patients developed late PTS without any early PTS. The results of our study show that among 23% early PTS and 11% late PTS only 3 % actually required to use AED for at least 6months. To prevent this, 3% of the population 44% were using AED supplementary.

Conclusion:  In our study, the incidence of early and late PTS is comparable to the other studies. The non-judicious use of the anti-epileptic drug is common in our country which leads to an increase in the risk of drug resistance and cost-intensive for poor patients in developing countries as prophylactic and excessive use of anti-epileptics does not affect the PTE.

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Published
2021-06-25
Section
Original Articles