Incidence of Infection and Causative Organisms in Patients with Ventriculoperitoneal Shunting for Hydrocephalus

Authors

  • Dr. Naeem ul Ha Lady Reading Hospital, Peshawar
  • Dr. Mumtaz Ali Lady Reading Hospital, Peshawar
  • Dr. Muhammad Ishfaq Khattak Lady Reading Hospital, Peshawar
  • Dr. Muhammad Zahid Lady Reading Hospital, Peshawar

Keywords:

Incidence, Infection, Ventriculoperitoneal shunting, Hydrocephalus, Coagulase negative staphylococci

Abstract

Objective: To determine about the incidence of infection and causative organisms in patients with Ventriculoperitoneal shunting for hydrocephalus.

Materials and Methods: This retrospective observational study was carried out in the Department of Neurosurgery Lady Reading Hospital Peshawar, from Jan 2012 to Dec 2013 (one year). The medical record of all cases operated in last one year was checked from record room. Documentation was done according to Performa designed indicating age, sex, clinical features and type of microorganism. All patients of either sex and age with Previous Ventriculoperitoneal shunt surgery and Signs and symptoms suggestive of shunt infection were included in the study. While patients of previous Ventriculoperitoneal shunt with no signs and symptoms were excluded from the study. All the data were analyzed by SPSS 20 and results were represented in the form of graphs / tables.

Results: Total 82 patients were included in the study in which males were 50 (60.97%) and females were 32 (39.02%). All the patients were in the age range of 6 months to 75 years having mean age of 37.75 years ± 5 SD. 58 (70.73%) were in pediatric age group and 24 (29.26%) were adults. Regarding etiology congenital acquiductal stenosis was the leading cause in children’s having 22/58 (37.93%) and CNS tumors were the most common cause in adults having 10/24 (41.66%). Fever and vomiting were the most common mode of presentation with 66 (80%) cases. overall incidence of shunt infection was 12 (14.63%) in which the most common microorganism was coagulase negative staphylococci having 6/12 (50%) cases.

Conclusion: Shunt infection most commonly occur in children’s and coagulase negative staphylococci is the most common causative organism.

Abbreviations: CSF: Cerebrospinal Fluid.

Author Biographies

Dr. Naeem ul Ha, Lady Reading Hospital, Peshawar

Neurosurgery Unit

Dr. Mumtaz Ali, Lady Reading Hospital, Peshawar

Neurosurgery Unit

Dr. Muhammad Ishfaq Khattak, Lady Reading Hospital, Peshawar

Neurosurgery Unit

Dr. Muhammad Zahid, Lady Reading Hospital, Peshawar

Neurosurgery Unit

References

1. Schut L, Bruno LA: The Child with Hydrocephalus. Philadelphia: VJS arte National Hydrocephalus Foundation, Inc. 1977; 12: 12-6.
2. Bhasin RR, Chen MK, Pincus DW. Salvaging the “lost peritoneum” after ventriculoatrial shunt failures. Childs Nerv Syst. 2007; 23: 483-6.
3. Zhang J, Qu C, Wang Z, Wang C, Ding X, Pan S, et al. Improved ventriculoatrial shunt for cerebrospinal fluid diversion after multiple Ventriculoperitoneal shunt failures. Surg Neurol. 2009; 72 (1): 29-33.
4. Sarguna P, Lakshmi V. Ventriculoperitoneal shunt infections. Indian Journal of Medical Microbiology, 2006; 24 (1): 52-4.
5. Enger PO, Svendsen F, Wester K. CSF shunt infections in children: experiences from a population-based study. Acta Neurochir. 2003; 145: 243–8.
6. Ronan A, Hogg GG, Klug GL. Cerebrospinal flid shunt infections in children. Pediatr Infect Dis J. 1995; 14: 782–6.
7. Faillace WJ. A no-touch technique protocol to diminish cerebrospinal fluid shunt infection. Surg Neurol. 1995; 43: 344–50.
8. McClelland S, Hall WA. Postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures. Clin Infect Dis. 2007; 45: 55–9.
9. McGirt MJ, Zaas A, Fuchs HE, George TM, Kaye K, Sexton DJ. Risk factors for pediatric Ventriculoperitoneal shunt infection and predictors of infectious pathogens. Clin Infect Dis. 2003; 36: 858–62.
10. Kulkarni AV, Drake JM, Lamberti – Pasculli M. Cerebrospinal fluid shunt infection: a prospective study of risk factors. J Neurosurg. 2001; 94: 195–201.
11. Renier D, Lacombe J, Pierre – Kahn A, Sainte – Rose C, Hirsch JF. Factors causing acute shunt infection: computer analysis of 1174 operations. J Neurosurg. 1984; 61: 1072–8.
12. Pople IK, Bayston R, Hayward RD. Infection of cerebrospinal fluid shunts in infants: a study of etiological factors. J Neurosurg. 1992; 77: 32–6.
13. Bayston R, Leung TS, Wilkins BM, Hodges B. Bacteriological examination of removed cerebrospinal fluid shunts. J Clin Pathol. 1983; 36: 987–90.
14. Shapiro S, Boaz J, Kleiman M, Kalsbeck J, Mealey J. Origin of organisms infecting ventricular shunts. Neurosurgery, 1988; 22: 868–72.
15. Wang KW. Infection of cerebrospinal fluid shunts” causative pathogens, clinical features, and outcomes. J infect Dis. 2004; 57: 44-8.
16. Choux M, Genitori L, Lang D, Lena G. Shunt implantation: reducing the incidence of shunt infection. J Neurosurg. 1992; 77: 875-80.
17. Lima MM, Pereira CU, Silva AM. Infecções em dispositivos neurológicos implantáveis em crianças e adolescentes. Arq Neuropsiquiatr. 2007; 65 (1): 118-23.
18. Arnell K, Enblad P, Wester T, Sjölin J. Treatment of cerebrospinal flid shunt infections in children using systemic and intraventricular antibiotic therapy in combination with externalization of the ventricular catheter: efficacy in 34 consecutively treated infections. J Neurosurg. 2007; 107 (3): 213-19.
19. Kestle JR, Garton HJ, Whitehead WE. Management of shunt infections: a multicenter pilot study. J Neurosurg. 2006; 105: 177-81.
20. Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood Hydrocephalus. J Neurosurg. 2007; 106: 334-9.
21. Wang KW, Chang WN, Shih TY. Infection of cerebrospinal fluid shunts: causative pathogens, clinical features, and outcomes. Jpn J Infect Dis. 2004; 57: 44–8.
22. Morissette I, Gourdeau M, Francoeur J. CSF shunt infections: a fifteen year experience with emphasis on management and outcome. Can J Neurol Sci. 1993; 20: 118–22.
23. Kanev PM, Sheehan JM. Reflections on shunt infection. Pediatr Neurosurg. 2003; 39: 285–90.
24. Kulkarni AV, Rabin D, Lamberti-Pasculli M, Drake JM. Repeat cerebrospinal fluid shunt infection in children. Pediatr Neurosurg. 2001; 35: 66–71.
25. Bhatnagar V, Mitra DK, Upadhyaya P. Shunt related infections in hydrocephalic children. Indian Pediatr. 1986; 23: 255–7.
26. Bhatnagar V, George J, Mitra DK, Upadhyaya P. Complications of cerebrospinal fluid shunts. Indian J Pediatr 1983; 50: 133–8.
27. Nicholas JL Etal,. Immediate shunt replacement in the treatment of bacterial colonization of Holter valves. Dev Med Child Neurol. 1970; 22: 110.
28. Stephen C et al. Infections of Cerebrospinal Fluid Shunts: Epidemiology, Clinical Manifestations, and Therapy. The Journal of Infectious Diseases, May 1975; Vol. 131, No. 5.
29. Borgbjerg BM, Gjerris F, Albeck MJ, Borgesen SE. Risk of infection after cerebrospinal fluid shunt: an analysis of 884 first – time shunts. Acta Neurochir (Wien), 1995; 136: 1–7.
30. Braga MH, Carvalho GT, Brandao RA, Lima FB, Costa BS: Early shunt complications in 46 children with hydrocephalus. Arq Neuropsiquiatr. 2009; 67: 273-7.
31. James HE, Bradley JS: Aggressive management of shunt infection: combined intravenous and intraventricular antibiotic therapy for twelve or less days. Pediatr Neurosurg. 2008; 44: 104-111.
32. 2000; 20 (1): 11-13. 6. Celik I, Erol FS, Cihangiroglu M, Akdemir I, Tiftikci M: Evaluation of the cases with VP shunt infections. Turkish Journal of Antibiotic and Chemotherapy, 2003; l 7(1): 60-4.
33. Ersahin Y, Mutluer S, Guzelbag E: Cerebrospinal fluid shunt infections. J Neurol Sci 1994; 38: 161–165.
34. Schoenbaum SC, Gardner P, Shillito J. Infections of cerebrospinal fluid shunts: epidemiology, clinical manifestations, and therapy. J Infect Dis. 1975; 131: 543-52.
35. James HE, Walsh JW, Wilson HO, Connor JD, Bean JR, Tibbs PA. Prospective randomized study of therapy in cerebrospinal fluid shunt infection. Neurosurgery, 1980; 7: 459-63.
36. Bayston R, Lari J. A study of sources of infection in colonized shunts. Dev Med Child Neurol. 1974; 16: 16– 22.
37. Stamos JK, Kaufman BA, Yogev R. Ventriculoperitoneal shunt infections with Gram negative bacteria. Neurosurgery, 1983; 33: 858–62.
38. Bisno AL, Sternau L: Infections of central nervous system shunts. In Infections Associated with Indwelling Medical Devices Edited by: Bisno AL, Waldvogel FA. American Society for Microbiology, Washington; 1994: 91-109.
39. Crnich CJ, Safdar N, Maki DG: Infections associated with implanted medical devices. In Antibiotic and Chemotherapy: Anti-Infective Agents and Their Use in Therapy 8th edition. Edited by: Finch RG, Greenwood D, Norrby SR, Whitley RJ. Churchill Livingstone 2003: 575-618.
40. Naradzay JFX, Browne BJ, Rolnick MA, Doherty RJ: Cerebral ventricular shunts. Journal of Emergency Medicine, 1999; 17 (2): 311-322.
41. Filka J, Huttova M, Tuharsky J, Sagat T, Kralinsky K, Kremery VJ: Nosocomial meningitis in children after ventriculoperitoneal shunt insertion. Acta Pediatr. 1999; 88 (5): 576-578.

Downloads

Published

2015-12-25

Issue

Section

Original Articles