Correlation Between Polycystic Ovary Syndrome and Neuropsychiatric Manifestations: Clinical and Hormonal Perspectives

Abstract

Objective:  Polycystic Ovary Syndrome is a prevalent endocrine illness in women of reproductive age, and it is becoming increasingly linked to neuropsychiatric disturbances. Hormonal imbalance, insulin resistance and chronic inflammation are possible contributors to psychological morbidity among the affected women. The study aimed to establish the relationship between Polycystic Ovary Syndrome and neuropsychiatric manifestations, both in clinical and hormonal aspects.

Materials & Methods:  This is an analytical cross-sectional study that was done within Lady Reading Hospital. Three hundred women aged from 18 to 40 years were recruited, 150 of whom were diagnosed with Polycystic Ovary Syndrome who met the Rotterdam criteria, and 150 healthy women were age-matched. Clinical and anthropometric parameters, hormonal status, metabolic parameters and inflammatory markers were measured. Psychological scales were used in measuring depression and anxiety.

Results:  Females with PCOS had significantly higher BMI, serum levels of T, fasting insulin levels and HOMA IR value compared to the controls. Moderate to severe depressive symptoms were found in 46 percent, and clinically significant anxiety symptoms were found in 52 percent. The score of depression and anxiety was positively correlated with total testosterone and insulin resistance. The mild yet significant association between C-reactive protein and anxiety symptoms was also found.

Conclusion:  Polycystic Ovary Syndrome has a strong correlation with the neuropsychiatric symptoms. The imbalance in hormones and dysfunction of the metabolism seem to be a significant factor in psychological distress. It is important to perform an endocrine and mental health evaluation as part of the management.