Management of Cervical Neurofibroma Type

Authors

  • FAROOQ AZAM Department of Neurosurgery, Hayatabad Medical Complex Hospital, Peshawar Khyber Pakhtoonkhawa
  • MIAN IFTIKHAR-UL-HAQ Department of Neurosurgery, Hayatabad Medical Complex Hospital, Peshawar Khyber Pakhtoonkhawa
  • MUSHTAQ Ali Noman Department of Neurosurgery, Hayatabad Medical Complex Hospital, Peshawar Khyber Pakhtoonkhawa
  • Riaz -ur-Rehman Department of Neurosurgery, Hayatabad Medical Complex Hospital, Peshawar Khyber Pakhtoonkhawa
  • Mewat Shah Department of Neurosurgery, Hayatabad Medical Complex Hospital, Peshawar Khyber Pakhtoonkhawa

Keywords:

Cervical neurofibroma type 1, spinal tumor,, cervical tumor.

Abstract

Objective: To determine the clinical presentation and postoperative outcome of cervical neurofibroma type 1.
Study design: Retrospective study.
Place and Duration of Study: Hayatabad Medical Complex Hospital Peshawar Khyber pakhtoonkhawa from 1st February 1999 to 31st July 2011.
Material and Methods: A total 41 patients with symptomatic cervical spine neurofibromas who underwent surgical decompression and tumor resection were included in this study. Both gender (male and female) and patients in the age range of 20 – 70 years were included in this study. These patients were operated through posterior approach of the cervical spine and then followed for six months for postoperative outcome .The patients’ demographic details and clinical manifestation were entered into a semi structured proforma. Data was analyzed through statistical program SPSS version 11.
Results: Out of 41 patients, there were 22 (53.6%) males and 19 (46.3%) females. The age of patients ranged from 20 to 70 years. In this study the overall mean age was 39.2 years. Majority of patients 19 (46.3%) were in the age range of 31 – 40 years. Most common clinical presentation of patient were quadrapresis in 23 (56.1%) pain neck 9 (22%) paraparesis 9 (22%) patients. Postoperatively most of the patients recovered from their preoperative symptoms.
Conclusions: Quadraparesis and pain neck were the common clinical presentation of cervical cord neurofibroma type 1. Surgical outcome of cevical neurofibroma type 1 is good.

References

1. Tonogai I, Sakai T, Katoh S, Higashino K, Sairyo K, Hirohashi N et al. Myelopathy in a 6 – year – old girl caused by neurofibromatosis Type 1: a case report. Spine J 2008; 8: 836-40.
2. Plotkin SR, O'Donnell CC, Curry WT, Bove CM, Mac-Collin M, Nunes FP. Spinal ependymomas in neuro-fibromatosis Type 2: a retrospective analysis of 55 pati-ents. J Neurosurg Spine. 2011 Apr; 14 (4): 543-7.
3. Cheong JH, Kim CH, Kim JM, Oh YH. Transformation of intracranial anaplastic astrocytoma associated with neurofibromatosis type I into gliosarcoma: case report. Clin Neurol Neurosurg 2010; 112: 701-6.
4. Alexiou GA, Panagopoulos D, Sfakianos G, Prodromou N. Cervical neurofibroma in a child without neuro-fibromatosis. Pediatr Emerg Care. 2010 Oct; 26 (10): 784-5.
5. Ng ES, Ong CK, Wilder – Smith E. Neurological picture. Traumatic upper limb weakness in a man with type 1 neurofibromatosis.J Neurol Neurosurg Psychia-try 2011; 82: 883-4.
6. Perera NR, Senevirathna LN, de Alwis DS, Perera SS. A rare cervical spine abnormality associated with neu-rofibromatosis. Ceylon Med J 2006; 51: 148-9.
7. Sarica FB, Cekinmez M, Tufan K, Erdo?an B, Sen O, Altinörs MN. A rare case of massive NF1 with invasion of entire spinal axis by neurofibromas: case report. Turk Neurosurg 2008; 18: 99-106.
8. Herrero VA, Moiron SR, Mera CJ, Palma T. Headache in patient with neurofibromatosis type 1. Neurologia 2007; 22: 911-4.
9. Charfeddine I, Mnejja M, Hammami B, Hasnaoui M, Hadj KA, Frikha I et al. (Neurofibromatosis type 1 revealed by malignant peripheral nerve sheath tumor0. Rev Laryngol Otol Rhinol (Bord) 2009; 130: 327-30.
10. Taleb FS, Guha A, Arnold PM, Fehlings MG, Mas-sicotte EM. Surgical management of cervical spine ma-nifestations of neurofibromatosis Type 1: long-term cli-nical and radiological follow-up in 22 cases. J Neuro-surg Spine 2011; 14: 356-66.
11. Leonard JR, Ferner RE, Thomas N, Gutmann DH. Cer-vical cord compression from plexiform neurofibromas in neurofibromatosis 1. J Neurol Neurosurg Psychiatry 2007; 78: 1404-6.
12. Ma J, Wu Z, Yang X, Xiao J.Surgical treatment of severe cervical dystrophic kyphosis due to neurofib-romatosis Type 1: a review of 8 cases. J Neurosurg Spine 2011; 14: 93-8.
13. Scheithauer BW, Erdogan S, Rodriguez FJ, Burger PC, Woodruff JM, Kros JM et al. Malignant peripheral ner-ve sheath tumors of cranial nerves and intracranial con-tents: a clinicopathologic study of 17 cases. Am J Surg Pathol 2009; 33: 325-38.
14. Matti TS, Matti JJ, Risto JS,JUHA EJ. Long – term outcome after removal of

Downloads

Published

2018-11-04

Issue

Vol. 15 No. 2 (2011): July-December

Section

Original Articles

License

The work published by PJNS is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Copyrights on any open access article published by Pakistan Journal of Neurological Surgery are retained by the author(s).