Role of Endoscopic Assisted Microsurgery for Pituitary Tumors

Authors

  • Hamad Nasir Assistant Professor, Department of Neurosurgery, PGMI / Lahore General Hospital, Lahore
  • M Ajmal Khan Department of Neurosurgery, PGMI / Lahore General Hospital, Lahore
  • Mukhtiar Ahmed Department of Neurosurgery, PGMI / Lahore General Hospital, Lahore
  • Waheed . Department of Neurosurgery, PGMI / Lahore General Hospital, Lahore
  • Muhammad Anwar Chaudary Department of Neurosurgery, PGMI / Lahore General Hospital, Lahore

Keywords:

Endoscopic, microsurgery, pituitary tumors, Gross tumor removal, visual field.

Abstract

Objective: To determine the outcome of endoscopic assisted microsurgery for pituitary tumors in terms of gross tumor removal and visual field improvement.
Materials and Methods: This Descriptive case series conducted at Department of Neurosurgery, Lahore General Hospital Lahore over a period of six months from July 2012 to December 2012. Sixty five patients were included through non-probability purposive sampling technique. All cases of pituitary tumor diagnosed on MRI/CT scan of either gender having age 18 – 80 years and patients with recurrent cases, sellar and with suprasellar extension (assessed on CT and MRI findings). Informed consent was taken from the patients. All laboratory tests were done in hospital laboratory and reported by hospital pathologist Shaukat Khanum Memorial Hospital Lahore. Pre- and post-operative visual field status (at least 3 months after surgery) was analyzed. Surgery was performed by a single team of surgeons. Surgical procedure involves introduction of 4-mm to 2.7mm endoscope to visualize the sphenoethmoid recess. The bilateral sphenoid Ostia are entered. The posterior nasal septum was incised at middle turbinate and it was patients resected. All the data was entered and analyzed by using SPSS 20. Fre-quency and percentages were calculated for all qualitative variables like gross removal rate and visual filed improvement.
Results: The mean age of the patients was 50.46 ± 17.80 years. There were 64.62% male patients and 35.38% female patients. Gross removal of tumor was observed in 56 (86.2%) and visual field improvement was found in 92.31% patients. 56 patients were those in which gross removal of tumor was observed in which 34 were males and 22 were females, similarly in 9 patients them was subtotal resection of tumor in which 8 were males and only 1 was female.
Conclusion: In this study, gross removal of tumor as well as visual field improvement was found in maximum number of patients and it is concluded that endoscopic assisted microsurgery for pituitary tumors is a better technique for such surgeries. 

References

DM, Snyder PJ. Clinically silent somatotroph adeno-mas are common. Eur J Endocrinol. 2011; 165 (1): 39-44.
2. Zada G, Woodmansee WW, Ramkissoon S, Amadio J, Nose V, Laws Jr ER. Atypical pituitary adenomas: incidence, clinical characteristics, and implications: J Neurosurg. 2011; 114 (2): 336-44.
3. Fernandez A, Karavitaki N, Wass JA. Prevalence of pituitary adenomas: a community – based, cross – sec-tional study in Banbury (Oxfordshire, UK). Clin Endo-crinol. 2010; 72 (3): 377-82.
4. Mezosi E, Nemes O. Treatment of pituitary adenomas. Orvosi hetilap. 2009; 150 (39): 1803-10.
5. Asa SL. Practical pituitary pathology: what does the pathologist need to know? Archives Pathol Laboratory Med. 2008; 132 (8): 1231-40.
6. Lubina A, Olchovsky D, Berezin M, Ram Z, Hadani M, Shimon I. Management of pituitary apoplexy: clini-cal experience with 40 patients. Acta neurochirurgica. 2005; 147 (2): 151-7.
7. Vance ML. Treatment of Pituitary Adenomas, 2013.
8. Castro DG, Cecilio S, Canteras MM. Radiosurgery for pituitary adenomas: evaluation of its efficacy and saf-ety. Radiat Oncol. 2010; 5: 109-13.
9. Cho D-Y, Liau W-R. Comparison of endonasal endo-scopic surgery and sublabial microsurgery for prolacti-nomas. Surg neurol. 2002; 58 (6): 371-5.
10. Cappabianca P, Cavallo LM, de Divitiis E. Endoscopic endonasal trans-sphenoidal surgery. Neurosurgery, 2004; 55 (4): 933-41.
11. Tabaee A, Anand VK, Barrón Y, Hiltzik DH, Brown SM, Kacker A, et al. Endoscopic pituitary surgery: a systematic review and meta-analysis: Clinical article. J Neurosurg. 2009; 111 (3): 545-54.
12. Ayub S, Mumtaz Ali M, Hayat F, Usman M, Naeem-ul-Haq, Ishaq M, et al. influence on visual deficit after transsphenoidal hypophysectomy for pituitary adeno-mas. JSZMC. 2003; 20 (1): 113-7.
13. Cho D-Y, Liau W-R. Comparison of endonasal endo-scopic surgery and sublabial microsurgery for prolacti-nomas. Surgical Neurology, 2002; 58 (6): 371-5.
14. Tabaee A, Anand VK, Barrón Y, Hiltzik DH, Brown SM, Kacker A, et al. Endoscopic pituitary surgery: a systematic review and meta-analysis: Clinical article. Journal of neurosurgery, 2009; 111 (3): 545-54.
15. Locatelli D, Massimi L, Rigante M, Custodi V, Palu-detti G, Castelnuovo P, et al. Endoscopic endonasal transsphenoidal surgery for sellar tumors in children. International journal of pediatric otorhinolaryngology, 2010; 74 (11): 1298-302.
16. Arbolay O, González J, González R, Gálvez Y. Exten-ded endoscopic endonasal approach to the skull base. Minimally Invasive Neurosurgery, 2009; 52 (3): 114.
17. Ceylan S, Koc K, Anik I. Extended endoscopic approa-ches for midline skull – base lesions. Neurosurgical review, 2009; 32 (3): 309-19.
18. Couldwell WT, Weiss MH, Rabb C, Liu JK, Apfel-baum RI, Fukushima T. Variations on the standard transsphenoidal approach to the sellar region, with emphasis on the extended approaches and parasellar approaches: surgical experience in 105 cases. Neuro-surgery, 2004; 55 (3): 539-50.
19. Greenfield J, Leng L, Chaudhry U, Brown S, Anand V, Souweidane M, et al. Combined simultaneous endosco-pic transsphenoidal and endoscopic transventricular resection of a giant pituitary macroadenoma. Mini-mally Invasive Neurosurgery, 2008; 51 (05): 306-9.
20. Ojha BK, Husain M, Rastogi M, Chandra A, Chugh A, Husain N. Combined trans-sphenoidal and simultane-ous trans-ventricular – endoscopic decompression of a giant pituitary adenoma: case report. Acta neurochirur-gica. 2009; 151 (7): 843-7.
21. Kassam AB, Prevedello DM, Thomas A, Gardner P, Mintz A, Snyderman C, et al. Endoscopic endonasal pituitary transposition for a transdorsum sellae appro-ach to the interpeduncular cistern. Neurosurgery, 2008; 62 (3): 57-74.
22. Di Maio S, Cavallo LM, Esposito F, Stagno V, Cor-riero OV, Cappabianca P. Extended endoscopic endo-nasal approach for selected pituitary adenomas: early experience: Clinical article. Journal of neurosurgery, 2011; 114 (2): 345-53.
23. Daly AF, Rixhon M, Adam C, Dempegioti A, Ticho-mirowa MA, Beckers A. High prevalence of pituitary adenomas: a cross – sectional study in the province of Liege, Belgium. The Journal of Clinical Endocrinology and Metabolism, 2006; 91 (12): 4769-75.
24. Kristof RA, Kirchhofer D, Handzel D, Neuloh G, Sch-ramm J, Mueller C-A, et al. Pre-existing chiasma synd-romes do not entirely remit following transsphenoidal surgery for pituitary adenomas. Acta neurochirurgica. 2011; 153 (1): 26-32.
25. Sanai N, Quinones – Hinojosa A, Narvid J, Kunwar S. Safety and efficacy of the direct endonasal transsphe-noidal approach for challenging sellar tumors. Journal of Neuro-oncology, 2008; 87 (3): 317-25.
26. Zhang X, Fei Z, Zhang W, Zhang J-n, Liu W-p, Fu L-a, et al. Endoscopic endonasal transsphenoidal surgery for invasive pituitary adenoma. Journal of Clinical Neuro-science, 2008; 15 (3): 241-5.
27. Dehdashti AR, Ganna A, Karabatsou K, Gentili F. Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series. Neurosurgery, 2008; 62 (5): 1006-17.
28. Ammirati M, Wei L, Ciric I. Short-term outcome of endoscopic versus microscopic pituitary adenoma sur-gery: a systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 2012: jnnp-2012-303194.
29. Tam S, Duggal N, Rotenberg BW, editors. Olfactory outcomes following endoscopic pituitary surgery with or without septal flap reconstruction: a randomized controlled trial. International forum of allergy & rhino-logy, 2013: Wiley Online Library.
30. Castro MCMd, Michel LMP, Denaro MMdC, Gontijo PAM, Sousa AAd. Endoscopic transnasal approach for removing pituitary tumors. Arquivos de neuro-psiquia-tria. 2014; 72 (5): 378-82.
31. Jho H-D. Endoscopic transsphenoidal surgery. Journal of Neuro-oncology, 2001; 54 (2): 187-95.
32. Lucas JW, Zada G. Endoscopic surgery for pituitary tumors. Neurosurgery Clinics of North America, 2012; 23 (4): 555-69.

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Published

2018-09-25

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