Management and Outcome of Severe Traumatic Brain Injury

Authors

  • Arfa Qasim
  • Lal Rehman
  • Iram Bokhari
  • Farrukh Javeed
  • Haris Hamid
  • Rubab Qadir

DOI:

https://doi.org/10.36552/pjns.v27i2.852

Abstract

Objective:  To assess the management of patients with severe traumatic brain injury and their outcomes.

Materials and Methods:  A prospective observational study was conducted at the Department of Neurosurgery of a tertiary care hospital. Our study included 279 patients in total. After meeting the requirements for inclusion, the patient's baseline information, such as age, gender, arrival GCS, and outcome, were noted. Three months of post-trauma observation were employed to assess the outcome. SPSS version 22.0 was used to evaluate the data obtained.

Results:  According to our study out of the total, 118 (42.3%) patients with severe TBI showed good outcomes while 161 (57.7%) showed poor outcomes at 3 months. In our study, the arrival GCS and arrival pupillary reactivity were statistically significant outcome factors (p = 0.040 and 0.010 respectively). Overall mortality was 35.13% (98) at 3 months.

Conclusion:  Patients presenting with severe TBI have high morbidity and mortality. Arrival GCS and pupillary reaction were important factors to significantly alter the outcome.

Keywords:  Traumatic Brain Injury, Glasgow Coma Score, Head Trauma, Glasgow Outcome Score, Outcome.

References

Crupi R, Cordaro M, Cuzzocrea S, Impellizzeri D. Management of Traumatic Brain Injury: From Present to Future. Antioxidants (Basel). 9 (4) :297.

Ruet A, Bayen E, Jourdan C, Ghout I, Meaude L, Lalanne A, Pradat-Diehl P, Nelson G, Charanton J, Aegerter P, Vallat-Azouvi C, Azouvi P. A Detailed Overview of Long-Term Outcomes in Severe Traumatic Brain Injury Eight Years Post-injury. Front Neurol. 2019; 10: 120.

Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. The impact of traumatic brain injuries: a global perspective. Neuro Rehabilitation, 2007; 22 (5): 341-53.

Road Safety Facts in the region of the Americas, 2013. Available at:

https://www.paho.org/hq/dmdocuments/2013/paho-roadsafe-facts-2013.pdf (Accessed: February 21, 2023).

Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974; 2 (7872): 81-4.

Kay, T. Neuropsychological treatment of mild traumatic brain injury. The Journal of Head Trauma Rehabilitation, 1993; 8 (3): 74–85.

Foulkes MA, Eisenberg HM, Jane JA, Marmarou A, Marshall LF. The Traumatic Coma Data Bank: design, methods, and baseline characteristics. Journal of Neurosurgery, 1991; 75 (Supplement): S8-13.

Zibara K, Ballout N, Mondello S, Karnib N, Ramadan N, Omais S, Nabbouh A, Caliz D, Clavijo A, Hu Z, Ghanem N. Combination of drug and stem cells neurotherapy: Potential interventions in neurotrauma and traumatic brain injury. Neuropharmacology, 2019; 145: 177-98.

Murray CJ, Lopez AD, World Health Organization. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020: summary. World Health Organization; 1996.

MRC Crash Trial Collaborators. Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients. BMJ. 2008; 336 (7641): 425-9.

Carney N, Totten AM, O’Reilly C, et al. Guidelines for the management of severe traumatic brain injury. Neurosurgery, 2017; 80: 6–15.

Faul M, Wald MM, Rutland-Brown W, Sullivent EE, Sattin RW. Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing the Brain Trauma Foundation guidelines for the treatment of severe traumatic brain injury. Journal of Trauma and Acute Care Surgery, 2007; 63 (6): 1271-8.

Jiang C, Cao J, Williamson C, Farzaneh N, Rajajee V, Gryak J, Najarian K, Soroushmehr SMR. Midline Shift vs. Mid-Surface Shift: Correlation with Outcome of Traumatic Brain Injuries. Proceedings (IEEE Int Conf Bioinformatics Biomed). 2019; 2019: 1083-1086.

Williamson T, Ryser MD, Ubel PA, Abdelgadir J, Spears CA, Liu B, Komisarow J, Lemmon ME, Elsamadicy A, Lad SP. Withdrawal of life-supporting treatment in severe traumatic brain injury. JAMA surgery, 2020; 155 (8): 723-31.

Bonow RH, Barber J, Temkin NR, Videtta W, Rondina C, Petroni G, et al. The outcome of severe traumatic brain injury in Latin America. World Neurosurgery, 2018; 111: e82-90.

Puffer RC, Yue JK, Mesley M, Billigen JB, Sharpless J, Fetzick AL, Puccio A, Diaz-Arrastia R, Okonkwo DO. Long-term outcome in traumatic brain injury patients with midline shift: a secondary analysis of the Phase 3 COBRIT clinical trial. Journal of Neurosurgery, 2018; 131 (2): 596-603.

Kraus JF, Epidemiology: In: Elizabeth F, ed. NINS. Head Injury Clinical Management and Research. Geneva, Switzerland: AIREN; 1990: 113–24.

McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS, Dikmen S, Stein M, Bodien YG, Boase K, Taylor SR. Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study. JAMA Neurology, 2021; 78 (8): 982-92.

Ruet A, Bayen E, Jourdan C, Ghout I, Meaude L, Lalanne A, Pradat-Diehl P, Nelson G, Charanton J, Aegerter P, Vallat-Azouvi C. A detailed overview of long-term outcomes in severe traumatic brain injury eight years post-injury. Frontiers in Neurology,. 2019; 10: 120.

Palekar SG, Jaiswal M, Patil M, Malpathak V. Outcome prediction in patients of traumatic brain injury based on midline shift on CT scan of brain. Indian Journal of Neurosurgery, 2021; 10 (03): 210–5.

Forslund MV, Perrin PB, Røe C, Sigurdardottir S, Hellstrøm T, Berntsen SA, Lu J, Arango-Lasprilla JC, Andelic N. Global outcome trajectories up to 10 years after moderate to severe traumatic brain injury. Frontiers in Neurology, 2019; 10: 219.

Fabbri A, Servadei F, Marchesini G, Stein SC, Vandelli A. Early predictors of unfavourable outcome in subjects with moderate head injury in the emergency department. J Neurol Neurosurg Psychiatry, 2008; 79 (5): 567–573.

Chiewvit P, Tritakarn SO, Nanta-aree S, Suthipongchai S. Degree of midline shift from CT scan predicted outcome in patients with head injuries. J Med Assoc Thai. 2010; 93 (1): 99–107.

Lipper MH, Kishore PR, Enas GG, Domingues da Silva AA, Choi SC, Becker DP. Computed tomography in the prediction of outcome in head injury. AJR Am J Roentgenol. 1985; 144: 483-6.

De Silva MJ, Roberts I, Perel P, Edwards P, Kenward MG, Fernandes J, Shakur H, Patel V. Patient outcome after traumatic brain injury in high-, middle-and low-income countries: analysis of data on 8927 patients in 46 countries. International Journal of Epidemiology, 2009; 38 (2): 452-8.

Hukkelhoven CW, Steyerberg EW, Farace E, Habbema JD, Marshall LF, Maas AI. Regional differences in patient characteristics, case management, and outcomes in traumatic brain injury: experience from the tirilazad trials. Journal of Neurosurgery, 2002; 97 (3): 549-57.

Williamson T, Ryser MD, Ubel PA, Abdelgadir J, Spears CA, Liu B, Komisarow J, Lemmon ME, Elsamadicy A, Lad SP. Withdrawal of life-supporting treatment in severe traumatic brain injury. JAMA Surgery, 2020; 155 (8): 723-31.

Downloads

Published

2023-06-09

Issue

Section

Original Articles