Common Histopathological spectrum of Posterior Fossa Tumors in Pediatric Age Group
Objective: To know about the common posterior fossa tumors in the pediatric age group on basis of Histopathology in Neurosurgery Department, Hayatabad Medical Complex Peshawar.
Material and Methods: This descriptive cross-sectional study was conducted in the department of MTI Hayatabad medical complex Peshawar from January 2017 to January 2020. We included a total of 52 patients who operated for posterior fossa tumors and biopsy reports were observed to know the histological pattern of the tumor. We included all those patients who have posterior fossa tumors except those tumors which involved or arise from brain stem and infections. The data was collected and analyzed using SPSS version 21.
Results: Our study shows that the mean age was 6 years with a standard deviation ± 2.81. Fifty-eight percent of children were male and 42% of children were female. Histopathologic patterns were analyzed as 48% of children had Medulloblastoma, 25% of children had Astrocytoma, 19% of children had Ependymoma, 8% of patients had other histopathologic patterns.
Conclusion: Our study concludes that common histopathologic patterns of posterior fossa tumors in children were medulloblastoma (48%), Astrocytoma (25%), ependymoma (19%) respectively.
2. Khan AA, Ali M, Ayub S, Khanzada K, Hussain R. Histological findings of posterior fossa tumors in children. J Postgrad Med Inst. 2010; 24 (1): 31-35.
3. Faheem KM, Jyothi V, Syama B. Pediatric tumors of central nervous system (CNS) – An epidemiopathologic research study. Int J Med Health Sci. 2012; 1(3): 73-82.
4. Nasir S, Jamila B, Khaleeq S. A retrospective study of primary brain tumors in children under 14 years of age at PIMS, Islamabad. Asian Pac J Cancer Prev. 2010; 11 (5): 1225-7.
5. Asirvatham JR, Deepti AN, Chyne R, Prasad M.S.N, Rajshekhar V, Chacko G. Pediatric tumors of the central nervous system: a retrospective study of 1,043 cases from a tertiary care center in South India. Childs Nerv Syst. 2011; 27 (8): 1257-63.
6. Karkouri M, Zafad S, Khattab M, Benjaafar N, ElKacemi H, Sefiani S, et al. Epidemiologic profile of pediatric brain tumors in Morocco. Childs Nerv Syst. 2010; 26 (8): 1021-7.
7. Saavedra FM, Pastrana EA, Jiménez LM, Fernandez M, Billoch J, Sosa I, et al. Pediatric brain tumors in Puerto Rico. P R Health Sci J. 2011; 30 (4): 195-7.
8. Makino K1, Nakamura H, Yano S, Kuratsu J, Kumamoto. Population-based epidemiological study of primary intracranial tumors in childhood. Childs Nerv Syst. 2010; 26 (8): 1029-34.
9. Alexiou GA, Moschovi M, Stefanaki K, G Sfakianos, N Prodromou. Epidemiology of pediatric brain tumors in Greece (1991-2008). Experience from the Agia Sofia Children's Hospital. Cent Eur Neurosurg. 2011; 72 (1): 1-4.
10. Jain A, Sharma MC, Suri V, Kale SS, Mahapatra AK, Tatke M, et al. Spectrum of pediatric brain tumors in India: a multi-institutional study. Neurol India, 2011; 59 (2): 208-11.
11. Nayil K, Makhdoomi R, Ramzan A, Zahoor S, Rasool M, Wani A, et al. Childhood tumors of the brain: demographic pattern over a ten-year period in the Kashmir Valley. Pediatr Neurosurg. 2011; 47 (1): 31-7.
12. O'Brien DF, Javadpour M, Collins DR, Spennato P, Mallucci CL. Endoscopic third ventriculostomy: An outcome analysis of primary cases and procedures performed after ventriculoperitoneal shunt
malfunction, 2005; 103 (5): 393-400.
13. Teo C, Jones R. Complications of endoscopic third ventriculostomy in previously shunted patients. Neurosurgery, 2008; (1) 63: 170-7.
14. Shaikh HA, Bokhari I, Rehman L, Babar AK, Siddiqui SH, Hashi AS. Surgical Outcome of Posterior Fossa Brain Tumors. J Surg Intern. 2014; 9 (1): 26-30.
15. Sajid H. Shah, Irshad N. Soomro, Akbar S. Hussainy, Sheema H. Hassan. Clinico-morphological Pattern of Intracranial Tumors in Children. PMA. 2013; 2: 1-6.
16. Rehman AU, Lodhi S, Murad S. Morphological Pattern of Posterior Cranial Fossa Tumors, 2009; 15 (2): 57-9
17. Paul H. Chapman, Eric Cosman, Michael Arnold. Telemetric ICP monitoring after surgery for posterior fossa and third ventricular tumors. Journal of Neurosurgery, 1984; 60 (3): 649651.
18. Drake JM, Kestle JR, Milner R, Cinalli G, Boop F, Piatt J Jr, et al. Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. Neurosurgery, 1998; 43: 294-3.
19. J Hyam, J Turner, D Peterson. Cerebellar haemorrhage after repeated burr hole evacuation for chronic subdural haematoma. Journal of Clinical Neuroscience, 2007; 14 (1): 83-6.
20. Hader WJ, Walker RL, Myles ST, Hamilton M. Complications of endoscopic third ventriculostomy in previously shunted patients, 2008; 63 (1) 74: 174-5.
21. Jenkinson MD, Hayhurst C, Al-Jumaily M, Kandasamy J, Clark S, Mallucci CL. The role of endoscopic third ventriculostomy in adult patients with hydrocephalus. J Neurosurg. 2009; 110: 861-6.
Copyright (c) 2022 Pakistan Journal Of Neurological Surgery
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.